Amino Science Labs sells research peptides exclusively to qualified researchers and laboratories for in vitro and laboratory use. Please confirm before continuing.
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Research Peptide
Epithalon for research
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Third-party tested
U.S. accredited labs
99%+ purity
HPLC verified
4AA
TETRAPEPTIDE
Ala-Glu-Asp-Gly (Epitalon)
Telomerase
TARGET
Activates telomerase enzyme
50+
PUBLICATIONS
By Prof. Khavinson since 2000s
33%
LIFESPAN
Extension in rodent models
390Da
MOL. WEIGHT
Synthetic pineal peptide
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on orders over $150
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Research
Epithalon (also written Epitalon or Epithalone) is a short synthetic tetrapeptide with the sequence Ala-Glu-Asp-Gly (alanyl-glutamyl-aspartyl-glycine). Assigned CAS number 307297-39-8 and the molecular formula C14H22N4O9, it is a four-residue peptide of roughly 390 g/mol supplied here at 10 mg per research vial. The sequence was derived as a synthetic analogue intended to correspond to the active core of a longer pineal-gland polypeptide preparation studied in the gerontology literature, and Epithalon is produced entirely by solid-phase synthesis rather than isolated from tissue. Because it is one of the smallest peptides frequently encountered in aging-related benchwork, it is often used as a compact, sequence-defined model compound in that research area.
Interest in Epithalon as a research material centers on how such a minimal, highly polar tetrapeptide behaves in cell-culture and preclinical systems, and on its reported in-vitro interactions with pathways associated with cellular senescence. It has no established consumer application. The surrounding body of work is preliminary and ongoing, is drawn largely from in-vitro assays and rodent or invertebrate models, and should not be extrapolated to human or animal outcomes.
Published investigations of Epithalon are predominantly in-vitro and animal-model in nature. A recurring line of inquiry involves telomere biology: cell-culture studies have examined whether exposure is associated with changes in telomerase activity and telomere length in cultured human somatic cell lines, making the peptide a frequently cited tool compound in senescence and replicative-lifespan assays. Other reported experimental endpoints include gene-expression and chromatin studies, circadian and melatonin-related signaling in pineal-tissue models, and lifespan or biomarker observations in rodent and Drosophila cohorts under controlled laboratory conditions.
These references describe experimental laboratory work only. They are not medical claims, are not evidence of safety or efficacy in humans or animals, and should not be interpreted as guidance for any use outside a controlled research environment. Findings remain preliminary and are not medical advice.
Each research lot is supplied as a lyophilized white powder and characterized before release. Identity and purity are established using orthogonal analytical methods so that the material on the Certificate of Analysis (COA) matches the sequence and mass expected for the Ala-Glu-Asp-Gly tetrapeptide. This dual approach separates purity (how much of the sample is the target peptide) from identity (confirmation that the target is the correct molecule).
The COA accompanying each product is the definitive analytical record for that specific lot. Because purity and mass can vary slightly between synthesis batches, researchers should reference the COA tied to the lot number received rather than generic specifications when documenting experimental inputs. Retaining the COA alongside experimental records supports reproducibility and traceability.
As a lyophilized peptide, Epithalon is hygroscopic and sensitive to repeated temperature cycling. Standard laboratory practice is to allow sealed vials to equilibrate to room temperature before opening to minimize condensation, and to reconstitute with an appropriate research-grade aqueous solvent under aseptic technique; the tetrapeptide's high polarity and acidic residues make it readily water-soluble. Aliquoting reconstituted stock into single-use portions limits freeze-thaw cycles that can degrade peptide integrity. Detailed temperature and stability windows for lyophilized, reconstituted, and working solutions appear in the storage table on this page.
Epithalon is a synthetic tetrapeptide with the sequence Ala-Glu-Asp-Gly, CAS 307297-39-8 and molecular formula C14H22N4O9 (about 390 g/mol). It is one of the smallest peptides commonly used in aging-related benchwork and is produced by solid-phase synthesis rather than isolated from tissue. Its short, sequence-defined structure is part of why it is used as a compact model compound in cell-culture research.
It ships as a lyophilized (freeze-dried) white powder in a sealed vial containing 10 mg of peptide. Lyophilization improves shelf stability for a research peptide and lets the researcher reconstitute it with a solvent of choice under aseptic conditions when preparing in-vitro experiments. Because the tetrapeptide is highly polar and acidic, it is readily soluble in aqueous research-grade solvents.
Purity is measured by reversed-phase HPLC and reported as a percentage of total peak area (greater than or equal to 98% on the COA for this lot), while identity is confirmed by mass spectrometry (ESI-MS or MALDI-TOF) against the theoretical mass for C14H22N4O9. Because Epithalon is small and hydrophilic, ion-pairing HPLC methods are often used to retain and resolve it. The lot-specific COA is the authoritative analytical record for the exact vial you receive.
Published work is predominantly in-vitro and animal-model. A prominent line of research examines telomerase activity and telomere length in cultured human somatic cell lines, alongside replicative-senescence assays, melatonin- and circadian-related signaling in pineal-tissue models, and lifespan or biomarker endpoints in rodent and Drosophila cohorts. This research is preliminary and ongoing, describes laboratory systems only, and does not establish any human or animal outcome.
This product is sold strictly for in-vitro research and laboratory use only. It is not intended for human or animal consumption, diagnostic purposes, or therapeutic application.
By purchasing this product, you confirm that you are a qualified researcher operating within an appropriate laboratory environment and will use this compound in accordance with all applicable local, state, and federal regulations.
Amino Science Labs assumes no liability for misuse of this product outside of its intended research application.
Allow the sealed vial to reach room temperature before opening to prevent condensation on the hygroscopic powder, reconstitute using aseptic technique with a research-grade aqueous solvent, and aliquot the stock to avoid repeated freeze-thaw cycles that can degrade peptide integrity. Follow the temperature and time windows in the storage table on this page for lyophilized, reconstituted, and working solutions.
No. This material is supplied strictly for in-vitro and laboratory research use by qualified researchers. It is not a drug, supplement, or food; it is not intended for human or animal consumption or for any diagnostic or therapeutic purpose; and nothing on this page constitutes medical advice.
