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Research Peptide
MT-2 for research
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Third-party tested
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99%+ purity
HPLC verified
7AA
CYCLIC PEPTIDE
Synthetic alpha-MSH analogue
MC1R
PRIMARY TARGET
Melanocortin-1 receptor
300+
PUBLICATIONS
In melanogenesis research
1991
FIRST SYNTHESIZED
University of Arizona
1024Da
MOL. WEIGHT
Ac-Nle-asp-His-DPhe-Arg-Trp-Lys-NH2
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Research
This listing supplies MT-2 (Melanotan II) as a lyophilized reference material for in-vitro and preclinical laboratory work. MT-2 is a synthetic cyclic heptapeptide analog of alpha-melanocyte-stimulating hormone (alpha-MSH), with the molecular formula C50H69N15O9 and CAS number 121062-08-6. Its defining structural feature is a lactam bridge that cyclizes the peptide backbone; this constraint holds the molecule in a conformation that laboratory studies report to be more resistant to enzymatic degradation than the linear native hormone, which is one reason MT-2 is frequently selected as a stable model ligand in melanocortin-receptor research. The material is produced synthetically and characterized as a discrete, sequence-defined heptapeptide rather than as an extract or blend.
In the literature MT-2 is classified as a non-selective melanocortin receptor agonist, meaning it engages several members of the melanocortin receptor family (notably MC1R, MC3R, MC4R, and MC5R) rather than a single subtype. That broad receptor engagement is why it is often used as a reference tool compound by researchers studying melanocortin signaling in cell-based systems. All descriptions below concern the research substance itself — its documented study history, its analytical fingerprint, and standard handling of freeze-dried peptide reference material — and are not statements about outcomes in humans or animals.
Published investigations involving MT-2 are predominantly receptor-pharmacology and cell-based in nature, using it as a reference agonist to study how the melanocortin receptor family transduces signals. Because it activates multiple receptor subtypes, it appears in assays measuring cyclic AMP (cAMP) accumulation and receptor binding across MC1R–MC5R constructs expressed in cultured cell lines. It is also cited in melanogenesis studies using cultured melanocyte and melanoma cell models, where researchers examine tyrosinase-related endpoints and pigment-pathway signaling in vitro under controlled conditions.
These references describe experimental laboratory work only. They are not medical claims, are not evidence of safety or efficacy in humans or animals, and should not be interpreted as guidance for any use outside a controlled research environment. Research on MT-2 remains preliminary and ongoing, and nothing here is medical advice.
Each research lot is supplied as a lyophilized powder at a stated peptide mass of 10 mg per vial and is characterized before release to a purity of at least 99%. Identity and purity are established using orthogonal analytical methods so that the material on the Certificate of Analysis (COA) matches the sequence and mass expected for the cyclic heptapeptide. This dual-method approach separates purity (how much of the sample is the target peptide) from identity (confirmation that the target is the correct molecule).
The COA accompanying each product is the definitive analytical record for that specific lot. Because purity and mass can vary slightly between synthesis batches, researchers should reference the COA tied to the lot number received rather than generic specifications when documenting experimental inputs. Retaining the COA alongside experimental records supports reproducibility and traceability.
As a lyophilized peptide, MT-2 is hygroscopic and sensitive to repeated temperature cycling. Standard laboratory practice is to allow sealed vials to equilibrate to room temperature before opening to minimize condensation, then reconstitute with an appropriate research-grade solvent under aseptic technique. Aliquoting reconstituted stock into single-use portions limits freeze-thaw cycles that can degrade peptide integrity, and protecting solutions from prolonged light exposure is prudent for melanocortin peptides. Detailed temperature and stability windows for lyophilized, reconstituted, and working solutions appear in the storage table on this page. All handling guidance refers to laboratory management of the material and does not describe or imply any use in humans or animals.
It ships as a lyophilized (freeze-dried) powder in a sealed vial containing 10 mg of peptide. Lyophilization improves shelf stability for a research peptide and lets the researcher reconstitute with a solvent of their choice under aseptic conditions when preparing in-vitro experiments. It is supplied as a discrete cyclic heptapeptide, not as a blend or extract.
Purity is measured by reversed-phase HPLC and reported as a percentage of total peak area (≥99% for this material), while identity is confirmed by mass spectrometry (ESI-MS or MALDI-TOF) against the theoretical mass for the molecular formula C50H69N15O9. The mass check also helps confirm the lactam-cyclized structure rather than an uncyclized precursor. The lot-specific COA documents these values and is the authoritative analytical record for the exact vial you receive.
MT-2 contains a lactam bridge that cyclizes its heptapeptide backbone, constraining the molecule into a fixed conformation. In the research literature this cyclization is associated with greater resistance to enzymatic degradation compared with the linear native hormone it is modeled on, which is one reason it is used as a stable tool compound in in-vitro melanocortin-receptor studies.
MT-2 is characterized as a non-selective melanocortin receptor agonist active across MC1R, MC3R, MC4R, and MC5R. It appears in cAMP-accumulation and radioligand-binding assays using receptor constructs in cultured cells, and in in-vitro melanogenesis and tyrosinase-pathway studies in melanocyte and melanoma cell models. This work is preliminary and ongoing and describes laboratory systems only, not human or animal outcomes.
This product is sold strictly for in-vitro research and laboratory use only. It is not intended for human or animal consumption, diagnostic purposes, or therapeutic application.
By purchasing this product, you confirm that you are a qualified researcher operating within an appropriate laboratory environment and will use this compound in accordance with all applicable local, state, and federal regulations.
Amino Science Labs assumes no liability for misuse of this product outside of its intended research application.
Allow the sealed vial to reach room temperature before opening to prevent condensation on the hygroscopic powder, reconstitute using aseptic technique with a research-grade solvent, protect solutions from prolonged light, and aliquot the stock to avoid repeated freeze-thaw cycles. Follow the temperature and time windows in the storage table on this page for lyophilized, reconstituted, and working solutions. This is laboratory handling guidance only.
No. This material is supplied strictly for in-vitro and laboratory research use by qualified researchers. It is not a drug, cosmetic, supplement, or food, is not intended for human or animal consumption or any diagnostic or therapeutic purpose, and nothing on this page constitutes medical advice.
