Amino Science Labs sells research peptides exclusively to qualified researchers and laboratories for in vitro and laboratory use. Please confirm before continuing.
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Research Peptide
MOTS-c peptide for research
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Research
MOTS-c (Mitochondrial Open reading frame of the Twelve S rRNA type-c) is a mitochondrial-derived peptide (MDP) encoded within the 12S rRNA region of the mitochondrial genome rather than the nuclear genome. First described in the scientific literature around 2015, it is a short 16-residue peptide (sequence MRWQEMGYIFYPRKLR) that has drawn attention in metabolic-signaling research. This listing supplies MOTS-c as a synthetic research peptide (CAS 1627580-64-6, molecular formula C101H152N28O22S2, approximately 2174 Da) intended strictly for in-vitro and preclinical laboratory investigation. It is not a drug, supplement, or article for human or veterinary use.
MOTS-c is studied as a member of the mitochondrial-derived peptide family alongside humanin and the SHLP series. Research interest centers on its proposed role as a signaling molecule involved in cellular metabolic homeostasis, and on the observation in published cell-based and rodent models that it can translocate to the nucleus under metabolic stress. These findings position MOTS-c as a tool compound for laboratory studies of mitochondrial-nuclear crosstalk; the underlying biology remains an active and preliminary area of investigation and the material here is offered only to support that experimental work.
Peer-reviewed reports have examined MOTS-c primarily in cultured cells and rodent models. Documented lines of laboratory inquiry include:
All described work is experimental and conducted in cell cultures or animal models. None of it establishes safety or efficacy in humans, and nothing here should be read as a medical or health claim. This content is educational and for laboratory research context only.
Because reproducible research depends on well-characterized material, each lot of this MOTS-c is specified at greater than or equal to 98% purity and is intended to ship with lot-specific analytical documentation. Typical characterization for a peptide of this class includes:
Reviewing the HPLC trace and mass-spec data before use is standard practice for peptide research, and researchers are encouraged to confirm identity and purity against their own acceptance criteria. Handling should follow ordinary laboratory practice for lyophilized peptides.
MOTS-c is a mitochondrial-derived peptide (MDP) encoded within the 12S rRNA region of the mitochondrial genome, rather than the nuclear genome. It is a 16-amino-acid peptide (sequence MRWQEMGYIFYPRKLR) studied in metabolic-signaling research. The material supplied here is a synthetic version (CAS 1627580-64-6) for in-vitro and preclinical laboratory use only.
Published work is largely in cultured cells and rodent models and has examined MOTS-c in the context of AMPK-pathway signaling, folate/methionine-cycle and glucose metabolism, and nuclear translocation under metabolic or oxidative stress. This research is preliminary and ongoing. It does not demonstrate any human health effect, and none of it should be interpreted as a medical claim.
Each lot is specified at greater than or equal to 98% purity. Identity and purity are typically confirmed by reversed-phase HPLC (main-peak area) and mass spectrometry (ESI-MS or MALDI-TOF), with the measured mass compared against the theoretical approximately 2174 Da for formula C101H152N28O22S2. A lot-specific Certificate of Analysis documents these results.
It is supplied as a lyophilized (freeze-dried) solid. Because the sequence contains two methionine residues (the source of the two sulfur atoms in the formula), it can be oxidation-sensitive, which researchers may factor into assay and storage design. Follow standard laboratory practice for handling lyophilized peptides; refer to the storage guidance shown separately on this page.
No. This product is a research chemical intended strictly for in-vitro and laboratory research. It is not a drug, dietary supplement, or article intended to diagnose, treat, cure, or prevent any condition, and it is not for human or veterinary administration.
This product is sold strictly for in-vitro research and laboratory use only. It is not intended for human or animal consumption, diagnostic purposes, or therapeutic application.
By purchasing this product, you confirm that you are a qualified researcher operating within an appropriate laboratory environment and will use this compound in accordance with all applicable local, state, and federal regulations.
Amino Science Labs assumes no liability for misuse of this product outside of its intended research application.
Reconstitution is determined by the individual research protocol and assay system, so no universal solvent or concentration is prescribed here. Peptides of this class are commonly evaluated for solubility in aqueous buffers or compatible cosolvents. Researchers should verify solubility empirically and prepare working solutions consistent with their experimental design and validated methods.
