Amino Science Labs sells research peptides exclusively to qualified researchers and laboratories for in vitro and laboratory use. Please confirm before continuing.
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Research Peptide
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Research
SS-31 is a synthetic, cell-permeable tetrapeptide belonging to the Szeto-Schiller (SS) family of aromatic-cationic peptides, from which its name derives. Its four-residue sequence (D-Arg-2',6'-dimethyl-L-Tyr-L-Lys-L-Phe-NH2, commonly written D-Arg-Dmt-Lys-Phe-NH2) incorporates a non-standard 2',6'-dimethyltyrosine residue and a D-arginine, features that distinguish it from ordinary linear peptides and that researchers cite when characterizing its stability and behavior. In the scientific literature the same compound also appears under the identifiers elamipretide and MTP-131, so laboratories cross-referencing published work should treat these names as pointing to the same tetrapeptide sequence. It is produced synthetically for laboratory use and has no established consumer application.
Interest in SS-31 as a research material centers on its documented tendency to associate with the inner mitochondrial membrane, a property that has made it a widely cited tool compound in mitochondrial and cell-biology investigations. Its alternating aromatic-cationic motif is the structural feature most often discussed in connection with membrane interaction and cellular uptake in cultured systems. The body of work surrounding the peptide remains preliminary and ongoing, and results from cell-based and rodent-model experiments should not be extrapolated to human or animal outcomes.
Published investigations of SS-31 are predominantly in-vitro and rodent-model in nature. Reported experimental lines of inquiry have used it as a probe for mitochondrial membrane behavior, examining endpoints such as cardiolipin association, mitochondrial membrane potential in isolated organelle and cultured-cell preparations, and reactive-oxygen-species readouts in controlled assay conditions. Because the peptide localizes to mitochondria in many cell-culture models, it is frequently employed as a reference compound in bioenergetics and oxidative-stress research rather than as a study subject in its own right.
These references describe experimental laboratory work only. They are not medical claims, are not evidence of safety or efficacy in humans or animals, and should not be interpreted as guidance for any use outside a controlled research environment.
Each research lot is supplied as a lyophilized powder and characterized before release. Identity and purity are established using orthogonal analytical methods so that the material described on the Certificate of Analysis (COA) matches the sequence and mass expected for the tetrapeptide. This dual-method approach separates purity — how much of the sample is the target peptide — from identity, which confirms the target is the correct molecule. The presence of the non-standard dimethyltyrosine residue means the theoretical mass differs from a peptide of ordinary tyrosine, so mass confirmation is a meaningful identity check for this specific sequence.
The COA accompanying each product is the definitive analytical record for that specific lot. Because purity and mass can vary slightly between synthesis batches, researchers should reference the COA tied to the lot number received rather than generic specifications when documenting experimental inputs. Retaining the COA alongside experimental records supports reproducibility and traceability.
As a lyophilized peptide, SS-31 is hygroscopic and sensitive to repeated temperature cycling. Standard laboratory practice is to allow sealed vials to equilibrate to room temperature before opening to minimize condensation, and to reconstitute with an appropriate research-grade solvent under aseptic technique. Aliquoting reconstituted stock into single-use portions limits the freeze-thaw cycles that can degrade peptide integrity. Detailed temperature and stability windows for lyophilized, reconstituted, and working solutions appear in the storage table on this page.
SS-31 is a synthetic aromatic-cationic tetrapeptide (D-Arg-Dmt-Lys-Phe-NH2) from the Szeto-Schiller peptide family. The same sequence is referenced in published research under the names elamipretide and MTP-131, so researchers cross-referencing studies should treat these identifiers as the same compound. It is supplied here strictly as a laboratory research material.
It ships as a lyophilized (freeze-dried) powder in a sealed vial, sized by peptide mass. Lyophilization improves shelf stability for a research peptide and lets the researcher reconstitute with a solvent of their choice under aseptic conditions when preparing in-vitro experiments. Consult the storage table on this page for handling windows.
Purity is measured by reversed-phase HPLC and reported as a percentage of total peak area, while identity is confirmed by mass spectrometry (ESI-MS or MALDI-TOF) against the theoretical mass of the D-Arg-Dmt-Lys-Phe-NH2 sequence, including its C-terminal amide. The lot-specific COA records both values plus appearance and net peptide content, and is the authoritative analytical record for the exact material you receive.
Published work is predominantly in-vitro and rodent-model, using SS-31 as a probe for mitochondrial membrane behavior, cardiolipin association, mitochondrial membrane potential, and oxidative-stress readouts in controlled assays. This research is preliminary and ongoing, describes laboratory systems only, and does not establish any human or animal outcome.
SS-31 contains a non-standard 2',6'-dimethyl-L-tyrosine residue rather than ordinary tyrosine, and a D-arginine at the N-terminus. These features shift the theoretical molecular mass relative to a conventional peptide of the same length, which is why mass-spectrometry confirmation against the expected value is a meaningful identity verification for this specific tetrapeptide.
This product is sold strictly for in-vitro research and laboratory use only. It is not intended for human or animal consumption, diagnostic purposes, or therapeutic application.
By purchasing this product, you confirm that you are a qualified researcher operating within an appropriate laboratory environment and will use this compound in accordance with all applicable local, state, and federal regulations.
Amino Science Labs assumes no liability for misuse of this product outside of its intended research application.
No. This material is supplied strictly for in-vitro and laboratory research use by qualified researchers. It is not a drug, supplement, or food, is not intended for human or animal consumption or any diagnostic or therapeutic purpose, and nothing on this page constitutes medical advice.
