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Research Peptide
A 3-amino acid tripeptide (Lys-Pro-Val) derived from the C-terminus of alpha-melanocyte-stimulating hormone that inhibits NF-κB activation via PepT1-mediated cellular uptake in preclinical inflammatory research models. Premium Research Peptide.
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Research
KPV is a synthetic tripeptide composed of three amino acids in sequence — L-lysine, L-proline, and L-valine (Lys-Pro-Val) — corresponding to the C-terminal residues of alpha-melanocyte-stimulating hormone (alpha-MSH). Because it reproduces only the terminal fragment of the parent 13-residue hormone rather than the full sequence, KPV is studied in the research literature as a minimal, sequence-defined peptide that retains reported activity associated with the alpha-MSH C-terminus while lacking the melanocortin-receptor pigment-signaling portion of the molecule. This listing supplies the free tripeptide (CAS 67727-97-3, C16H30N4O4) as a lyophilized reference material for in-vitro and preclinical laboratory work only.
Interest in KPV as a research material stems from its small size and its documented relationship to alpha-MSH. In published preclinical models, its reported activity is frequently linked to inhibition of NF-κB (nuclear factor kappa B) activation, a transcription-factor pathway central to inflammatory signaling, and to cellular uptake mediated by the peptide transporter PepT1 (SLC15A1) expressed on epithelial and immune cells. Investigators use it as a tool compound to probe how a short tripeptide is internalized and how it intersects with inflammatory transcriptional pathways in cultured cells. This body of work remains preliminary and ongoing, and cell-based or rodent-model findings should not be extrapolated to human or animal outcomes.
Published investigations of KPV are predominantly in-vitro and rodent-model in nature, typically using intestinal epithelial cell lines and cultured immune cells. Reported experimental lines of inquiry concern the peptide's route of entry through PepT1, its influence on NF-κB nuclear translocation and downstream pro-inflammatory cytokine expression in cell models, and its behavior in chemically induced colitis models used to study mucosal inflammation. Because KPV is a PepT1 substrate, some analytical work also examines transporter-mediated uptake kinetics relative to di- and tripeptide standards.
These references describe experimental laboratory work only. They are not medical claims, are not evidence of safety or efficacy in humans or animals, and should not be interpreted as guidance for any use outside a controlled research environment. Research on this compound is preliminary and ongoing.
Each research lot is supplied as a lyophilized powder and characterized before release, with a Certificate of Analysis (COA) that separates purity (how much of the sample is the target tripeptide) from identity (confirmation that the target is the correct molecule). For a short, sequence-defined tripeptide like KPV, the theoretical average mass calculated from the molecular formula C16H30N4O4 is approximately 342.4 Da, and mass-spectrometric identity testing is used to confirm the observed mass matches this expected value for the Lys-Pro-Val sequence.
The COA accompanying each product is the definitive analytical record for that specific lot. Because purity and net peptide content can vary slightly between synthesis batches, researchers should reference the COA tied to the lot number received rather than generic specifications when documenting experimental inputs and calculating stock concentrations. Retaining the COA alongside experimental records supports reproducibility and traceability.
As a lyophilized peptide, KPV is hygroscopic and sensitive to repeated temperature cycling. Standard laboratory practice is to allow sealed vials to equilibrate to room temperature before opening to minimize condensation, and to reconstitute with an appropriate research-grade solvent under aseptic technique. Aliquoting reconstituted stock into single-use portions limits freeze-thaw cycles that can degrade peptide integrity. Detailed temperature and stability windows for lyophilized, reconstituted, and working solutions appear in the storage table on this page. All handling described here is standard laboratory practice and is not instruction for human or animal use.
KPV is a synthetic three-amino-acid tripeptide (Lys-Pro-Val) corresponding to the C-terminal fragment of alpha-melanocyte-stimulating hormone (alpha-MSH). It is supplied here as a lyophilized reference material (CAS 67727-97-3, C16H30N4O4, ~342.4 Da) for in-vitro and preclinical laboratory research only. In published models its reported activity is associated with inhibition of NF-κB activation and with PepT1-mediated cellular uptake. It is a research chemical for laboratory use, not a therapeutic product, and not for human or animal consumption.
KPV reproduces the last three residues at the C-terminus of the 13-residue hormone alpha-MSH. Researchers study it as a minimal fragment because it captures the reported C-terminal activity of the parent peptide without the melanocortin-receptor pigment-signaling portion. Comparative in-vitro studies often contrast KPV with full-length alpha-MSH and with inactive control peptides. These are mechanistic, model-based observations and do not establish any effect in humans or animals.
Preclinical and in-vitro work describes two recurring themes: cellular entry through the peptide transporter PepT1 (SLC15A1), and influence on the NF-κB inflammatory signaling pathway, typically measured in intestinal epithelial and immune cell models via NF-κB nuclear translocation and downstream cytokine readouts. This research is preliminary and ongoing, describes laboratory systems only, and is not medical advice.
Purity is measured by reversed-phase HPLC and reported as a percentage of total peak area (specified here as ≥ 99%), while identity is confirmed by mass spectrometry (ESI-MS or MALDI-TOF) against the theoretical average mass of ~342.4 Da for the formula C16H30N4O4. The lot-specific COA documents both values plus appearance and net peptide content, and is the authoritative analytical record for the exact material received.
This product is sold strictly for in-vitro research and laboratory use only. It is not intended for human or animal consumption, diagnostic purposes, or therapeutic application.
By purchasing this product, you confirm that you are a qualified researcher operating within an appropriate laboratory environment and will use this compound in accordance with all applicable local, state, and federal regulations.
Amino Science Labs assumes no liability for misuse of this product outside of its intended research application.
Allow the sealed vial to reach room temperature before opening to prevent condensation on the hygroscopic powder, reconstitute using aseptic technique with a research-grade solvent, and aliquot the stock to avoid repeated freeze-thaw cycles. Follow the temperature and time windows in the storage table on this page for lyophilized, reconstituted, and working solutions. This is standard laboratory handling and not guidance for any human or animal use.
No. This material is supplied strictly for in-vitro and laboratory research use by qualified researchers. It is not a drug, supplement, or food, is not intended for human or animal consumption or any diagnostic or therapeutic purpose, and nothing on this page constitutes medical advice or a claim of safety or efficacy.
