Amino Science Labs sells research peptides exclusively to qualified researchers and laboratories for in vitro and laboratory use. Please confirm before continuing.
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Research Peptide
PT-141 for research
Fast shipping
Same-day dispatch
Third-party tested
U.S. accredited labs
99%+ purity
HPLC verified
7AA
HEPTAPEPTIDE
Cyclic MSH analogue (Bremelanotide)
MC4R
TARGET
Melanocortin-4 receptor agonist
2019
FDA APPROVED
As Vyleesi for HSDD
200+
PUBLICATIONS
In melanocortin pathway research
1-2hrs
ONSET
Peak effect timeframe in studies
Free shipping
on orders over $150
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Research
This listing supplies PT-141 (bremelanotide) as a 10 mg lyophilized research peptide for in-vitro and preclinical laboratory work only. PT-141 is a synthetic cyclic heptapeptide and a melanocortin-receptor ligand, structurally derived from the alpha-melanocyte-stimulating-hormone (alpha-MSH) family. It corresponds to the free-acid metabolite of the earlier melanocortin analog Melanotan II: where Melanotan II terminates in a C-terminal amide, PT-141 carries a carboxylic-acid terminus, a difference that distinguishes the two compounds analytically and is reflected in the molecular formula C50H68N14O10 and CAS 189691-06-3. The cyclic lactam bridge that constrains the peptide backbone is the defining structural feature investigators reference when characterizing it, because that ring rigidity is associated with its receptor-binding profile in laboratory assays.
In the research literature PT-141 is described as a non-selective melanocortin-receptor agonist, with reported activity at several receptor subtypes and particular interest in melanocortin-4 receptor (MC4R) and melanocortin-3 receptor (MC3R) engagement. Because it is categorized among hormone-pathway research compounds rather than as a simple structural peptide, it is typically studied as a tool for probing melanocortin G-protein-coupled-receptor (GPCR) signaling. The material offered here is intended solely as a characterized reference compound for that kind of controlled benchtop investigation, not for any other purpose.
The published work surrounding PT-141 is predominantly receptor-pharmacology and rodent-model research centered on the melanocortin system. The themes below are described strictly as observations in laboratory systems and are not statements about outcomes in humans or animals; the evidence base is preliminary and ongoing rather than settled.
Research Context
These references describe experimental laboratory work only. They are not medical claims, are not evidence of safety or efficacy in humans or animals, and should not be interpreted as guidance for any use outside a controlled research environment. Observations in isolated cells or rodent models do not establish results in other biological systems.
For a cyclic peptide bearing a free-acid terminus, analytical verification is central to reproducible results because both sequence fidelity and correct cyclization must be confirmed. Research-grade PT-141 is typically assessed by reversed-phase high-performance liquid chromatography (RP-HPLC) to quantify chromatographic purity, reported as the percentage of the main peak; lots on this listing are specified at greater than or equal to 99 percent. The chromatogram is used to resolve the target from process-related impurities, linear (uncyclized) sequences, and — importantly for this molecule — the amidated Melanotan II analog, which differs by a single terminal modification.
Identity is confirmed by mass spectrometry (commonly ESI-MS or MALDI-TOF), matching the observed mass against the theoretical value for the C50H68N14O10 composition (average molecular weight near 1025 g/mol for the free-acid form). This confirms both molecular identity and that the material is the carboxylic-acid PT-141 rather than the amidated parent. A lot-specific Certificate of Analysis (COA) documents these analyses along with net peptide content, since counter-ion (typically acetate) and residual water in a lyophilized powder mean the peptide mass in a given vial can differ from the gross fill weight. Confirming these figures against a current, lot-matched COA before use is standard practice and directly affects the accuracy of experimental concentrations.
The following describes conventional handling of lyophilized research peptides and is not instruction for human or animal use. As a freeze-dried powder, PT-141 is hygroscopic and sensitive to repeated temperature cycling, so sealed vials are allowed to equilibrate to room temperature before opening to minimize condensation. Reconstitution is performed with an appropriate research-grade solvent under aseptic technique, and reconstituted stock is commonly aliquoted into single-use portions to limit freeze-thaw cycles that can degrade peptide integrity. Detailed temperature and stability windows for lyophilized, reconstituted, and working solutions appear in the storage table elsewhere on this page. All handling follows standard institutional chemical-safety practice.
PT-141 (bremelanotide) is a synthetic cyclic heptapeptide melanocortin-receptor ligand supplied as a 10 mg lyophilized powder for in-vitro and preclinical laboratory research. It is the free-acid metabolite of Melanotan II: the two share a cyclic melanocortin scaffold, but PT-141 has a carboxylic-acid C-terminus where Melanotan II is amidated. That single terminal difference is reflected in its formula C50H68N14O10 and CAS 189691-06-3, and it is one of the impurities analytical methods are designed to resolve. It is a research chemical for laboratory use only, not a therapeutic product.
In laboratory settings PT-141 is characterized as a non-selective melanocortin-receptor agonist, with reported activity at melanocortin subtypes and particular research interest in MC4R and MC3R. Cell-based assays measure binding affinity and downstream cyclic-AMP signaling at these G-protein-coupled receptors, using native alpha-MSH as a comparator. These are mechanistic, model-based observations from preliminary and ongoing research and do not establish any effect in humans or animals.
Purity is assessed by reversed-phase HPLC and reported as a percentage of the main chromatographic peak, with lots on this listing specified at greater than or equal to 99 percent. Mass spectrometry (ESI-MS or MALDI-TOF) confirms the molecular mass against the C50H68N14O10 composition, verifying both identity and that the material is the free-acid form rather than the amidated Melanotan II analog. A lot-specific Certificate of Analysis records these results along with net peptide content.
A lyophilized peptide vial contains counter-ion (usually acetate) and residual water in addition to the peptide, so the net peptide mass can be lower than the gross 10 mg fill weight. Reviewing the lot-matched COA for reported net peptide content and HPLC purity lets researchers calculate accurate stock concentrations, which is essential for reproducible in-vitro work. Retaining the COA with experimental records also supports traceability between synthesis batches.
This product is sold strictly for in-vitro research and laboratory use only. It is not intended for human or animal consumption, diagnostic purposes, or therapeutic application.
By purchasing this product, you confirm that you are a qualified researcher operating within an appropriate laboratory environment and will use this compound in accordance with all applicable local, state, and federal regulations.
Amino Science Labs assumes no liability for misuse of this product outside of its intended research application.
As with other lyophilized research peptides, the sealed vial is allowed to reach room temperature before opening to prevent condensation on the hygroscopic powder, then reconstituted with a research-grade solvent under aseptic technique. Stock solutions are aliquoted to avoid repeated freeze-thaw cycles, which can degrade a cyclic peptide over time. Follow the temperature and time windows in the storage table on this page for lyophilized, reconstituted, and working solutions, along with your institution's safety requirements.
No. PT-141 here is supplied strictly for in-vitro and preclinical laboratory research by qualified researchers. It is not a drug, supplement, or food, is not formulated or tested for administration, and is not intended for human or animal consumption or for any diagnostic or therapeutic purpose. Nothing on this page constitutes medical advice or a claim of safety or efficacy.
