Amino Science Labs sells research peptides exclusively to qualified researchers and laboratories for in vitro and laboratory use. Please confirm before continuing.
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Research Peptide
HCG supplied for analytical and in-vitro research only.
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Same-day dispatch
Third-party tested
U.S. accredited labs
99%+ purity
HPLC verified
237AA
GLYCOPROTEIN
Alpha + Beta subunit heterodimer
LH/CG-R
TARGET RECEPTOR
Luteinizing hormone receptor
1920s
DISCOVERED
First isolated from pregnant urine
5000+
PUBLICATIONS
One of most studied hormones
36.7kDa
MOL. WEIGHT
Heavily glycosylated protein
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on orders over $150
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Research
Human chorionic gonadotropin (HCG; CAS 9002-61-3) is supplied here strictly for analytical and in-vitro laboratory research. Unlike the short synthetic peptides commonly stocked for benchtop work, HCG is a large, heterodimeric glycoprotein hormone comprising roughly 237 amino acids distributed across two non-covalently associated subunits: an alpha subunit shared with other pituitary glycoprotein hormones, and a beta subunit that confers the molecule's distinct identity. A defining structural feature is its extensive glycosylation — both N-linked and O-linked oligosaccharide chains attached along the protein backbone — which is why HCG behaves as a glycoprotein rather than a simple linear peptide in solution. Because in-vitro receptor activity depends on the intact, correctly paired heterodimer, researchers treat subunit association and carbohydrate integrity as central variables when planning identity checks, reconstitution, and storage.
Interest in HCG as a research material centers on its role as a well-characterized reference ligand for the luteinizing-hormone/chorionic-gonadotropin receptor (LHCGR), a class-A G-protein-coupled receptor. Its activity is reported in International Units (IU), a bioassay-referenced measure appropriate for a heterogeneous glycoprotein whose potency cannot be captured by mass alone; this listing is standardized to 5000 IU per vial. The body of published work surrounding HCG is extensive but remains, for the purposes of this material, a laboratory and preclinical reference point only. Findings from cell-based receptor assays and animal-model studies are preliminary in the context of any novel investigation and should not be extrapolated to human or animal outcomes. Nothing here constitutes medical advice.
Published investigations involving HCG are predominantly in-vitro receptor-pharmacology and rodent-model in nature. Reported experimental lines of inquiry include use of HCG as an agonist standard in cultured cells expressing the LHCGR, cyclic-AMP accumulation and second-messenger signaling assays, and steroidogenesis endpoints measured in isolated cell systems. It is also frequently used as a calibrated reference antigen in immunoassay development and validation. This research is preliminary and ongoing and describes laboratory systems only.
These references describe experimental laboratory work only. They are not medical claims, are not evidence of safety or efficacy in humans or animals, and should not be interpreted as guidance for any use outside a controlled research environment.
Each research lot is characterized before release so that the material described on the Certificate of Analysis (COA) matches the properties expected for a glycoprotein hormone. Characterizing a glycosylated heterodimer differs from characterizing a small synthetic peptide: mass is intrinsically heterogeneous because of variable glycan occupancy, so purity is assessed by chromatographic and electrophoretic profiling rather than by a single exact-mass value, and potency is expressed in IU against a bioassay-referenced standard. This lot is specified at ≥98% purity and 5000 IU.
The COA accompanying each product is the definitive analytical record for that specific lot. Because glycan composition, potency, and purity can vary slightly between production batches, researchers should reference the COA tied to the lot number received rather than generic specifications when documenting experimental inputs. Retaining the COA alongside experimental records supports reproducibility and traceability across assays that depend on a defined IU input.
As a lyophilized glycoprotein, HCG is hygroscopic and sensitive to heat, agitation, and repeated temperature cycling, any of which can promote subunit dissociation or aggregation and reduce measurable IU. Standard laboratory practice is to allow the sealed vial to equilibrate to room temperature before opening to minimize condensation, then to reconstitute gently with an appropriate research-grade aqueous solvent under aseptic technique — avoiding vigorous vortexing that can shear a large protein. Aliquoting reconstituted stock into single-use portions limits freeze-thaw cycles that degrade glycoprotein integrity. Detailed temperature and stability windows for lyophilized, reconstituted, and working solutions appear in the storage table on this page. These are standard laboratory handling notes only.
It ships as a lyophilized (freeze-dried) glycoprotein in a sealed vial standardized to 5000 International Units. Lyophilization improves shelf stability for a heterodimeric protein and lets the researcher reconstitute with a research-grade aqueous solvent of choice under aseptic conditions when preparing in-vitro experiments. It is a research chemical for laboratory use only.
HCG is a glycosylated heterodimer whose molecular mass is intrinsically heterogeneous because glycan occupancy varies. Mass alone therefore does not capture in-vitro functional activity, so potency is expressed in International Units (IU) referenced to a bioassay standard. This listing is standardized to 5000 IU, which is the appropriate potency metric for characterizing a glycoprotein hormone in receptor and calibration assays.
Purity is assessed by chromatographic methods such as RP-HPLC and size-exclusion HPLC (reported at ≥98% by peak area), while identity is characterized by mass spectrometry and SDS-PAGE that resolve the intact heterodimer and its alpha and beta subunits. Because of expected glycan heterogeneity, mass appears as a distribution rather than a single sharp value. The lot-specific COA documents purity, IU potency, appearance, and net protein content and is the authoritative record for the exact material received.
Published work is predominantly in-vitro and rodent-model, including its use as an agonist reference at the LHCGR in cell-based receptor assays, cAMP and second-messenger signaling studies, steroidogenesis endpoints in cultured cell systems, and immunoassay calibration where HCG serves as a characterized standard. This research is preliminary and ongoing, describes laboratory systems only, and does not establish any human or animal outcome.
This product is sold strictly for in-vitro research and laboratory use only. It is not intended for human or animal consumption, diagnostic purposes, or therapeutic application.
By purchasing this product, you confirm that you are a qualified researcher operating within an appropriate laboratory environment and will use this compound in accordance with all applicable local, state, and federal regulations.
Amino Science Labs assumes no liability for misuse of this product outside of its intended research application.
Allow the sealed vial to reach room temperature before opening to prevent condensation on the hygroscopic solid, then reconstitute gently with a research-grade aqueous solvent using aseptic technique, avoiding vigorous vortexing that can shear or denature the protein. Aliquot the stock to avoid repeated freeze-thaw cycles that promote subunit dissociation and loss of IU potency. Follow the temperature and time windows in the storage table on this page for lyophilized, reconstituted, and working solutions. These are standard laboratory handling practices, not usage instructions.
No. This material is supplied strictly for analytical and in-vitro laboratory research by qualified researchers. It is not a drug, supplement, or food, is not intended for human or animal consumption or any diagnostic or therapeutic purpose, and nothing on this page constitutes medical advice.
