Amino Science Labs sells research peptides exclusively to qualified researchers and laboratories for in vitro and laboratory use. Please confirm before continuing.
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Research Peptide
5-Amino-1-methylquinolinium (5-Amino-1MQ) is a small molecule inhibitor of nicotinamide N-methyltransferase (NNMT) that enhances metabolic function and cellular energy regulation. Research demonstrates 5-Amino-1MQ significantly reduces body weight and fat mass while preserving lean muscle tissue. Studies show treatment produces approximately 35% reduction in white adipose tissue mass and 5.1% body weight loss without affecting food intake. The compound increases intracellular NAD+ levels, enhancing mitochondrial function and metabolic efficiency. In aged mice, 5-Amino-1MQ improves grip strength by approximately 40%, enhances muscle regeneration capacity twofold, and increases contractile force by 70% following injury, demonstrating powerful effects on muscle preservation and recovery.
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TLR7
TARGET
Toll-like receptor 7 agonist
Imiquimod
CLASS
Immune response modifier
200+
PUBLICATIONS
In immunology research
1997
FDA APPROVED
Original imiquimod (Aldara)
IFN-α
INDUCES
Interferon-alpha production
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Research
5-AMINO-IMQ is an imidazoquinoline amine derivative supplied strictly as a laboratory research material for in-vitro and preclinical immunological studies. Structurally, imidazoquinoline amines belong to the same synthetic small-molecule family as imiquimod (R-837) and resiquimod (R-848), a class of compounds widely used in the research literature as chemical probes for the innate-immune Toll-like receptor pathway. As a defined synthetic small molecule rather than a peptide, it is provided as a solid research chemical intended only for controlled laboratory work by qualified investigators.
Interest in imidazoquinoline amine derivatives as research tools stems from their reported activity, in cell-based systems, at pattern-recognition receptors that innate-immune cells use to sense single-stranded viral RNA. Compounds in this class have been studied as agonists at Toll-like receptors 7 and 8 (TLR7/TLR8) in cultured cells, so researchers use them as tool compounds for dissecting innate-immune signaling and cytokine-induction pathways. The specific 5-amino-substituted derivative offered here is positioned for this kind of laboratory investigation. This body of work is preliminary and ongoing, describes laboratory systems only, and should not be extrapolated to human or animal outcomes; the compound has no established consumer application.
Published investigations of imidazoquinoline amine derivatives are predominantly in-vitro and rodent-model in nature. Reported experimental lines of inquiry for this chemical class include receptor-reporter assays characterizing TLR7/TLR8 engagement, measurement of interferon and other cytokine readouts in cultured immune-cell preparations, and structure-activity studies comparing how substitutions on the imidazoquinoline scaffold alter observed receptor interaction. These describe measurements recorded in specific controlled experiments, not predicted responses in any other system, and are not evidence of safety or efficacy.
These references describe experimental laboratory work only. They are not medical claims, are not evidence of safety or efficacy in humans or animals, and should not be interpreted as guidance for any use outside a controlled research environment.
Each research lot is supplied as a solid and characterized before release, with purity specified at greater than or equal to 98%. Identity and purity are established using orthogonal analytical methods so that the material described on the Certificate of Analysis (COA) matches the mass and structure expected for the imidazoquinoline amine derivative. This dual-method approach separates purity (how much of the sample is the target molecule) from identity (confirmation that the target is the correct structure).
The COA accompanying each product is the definitive analytical record for that specific lot. Because purity and residual-impurity profiles can vary slightly between synthesis batches, researchers should reference the COA tied to the lot number received rather than generic specifications when documenting experimental inputs. Retaining the COA alongside experimental records supports reproducibility and traceability across replicate studies.
As a small-molecule imidazoquinoline solid, 5-AMINO-IMQ is handled using standard laboratory practice: allow sealed vials to equilibrate to room temperature before opening to minimize condensation, and prepare stock solutions with an appropriate research-grade solvent under clean technique. Aliquoting dissolved stock into single-use portions limits repeated freeze-thaw cycles that can affect solution integrity. Detailed temperature and stability windows for the solid and for prepared working solutions appear in the storage table on this page.
5-AMINO-IMQ is an imidazoquinoline amine derivative supplied as a solid research chemical for in-vitro and preclinical immunological studies. Compounds in the imidazoquinoline class (which includes imiquimod and resiquimod) have been studied as chemical probes of the innate-immune Toll-like receptor 7/8 pathway in cultured cells. It is a laboratory research tool for qualified investigators, not a therapeutic, drug, or supplement.
It ships as a solid imidazoquinoline amine derivative in a sealed vial, sized by mass (10 mg). As a defined synthetic small molecule rather than a peptide, it is supplied for reconstitution with a researcher-selected, research-grade solvent under clean technique when preparing in-vitro or preclinical experiments.
Purity is measured by HPLC and reported as a percentage of total UV peak area (specified greater than or equal to 98%), while identity is confirmed by mass spectrometry (ESI-MS or LC-MS) against the theoretical mass for the imidazoquinoline amine derivative, with NMR used where applicable for structural confirmation. The lot-specific COA records these values plus appearance and is the authoritative analytical record for the exact material received.
Published work on imidazoquinoline amine derivatives is predominantly in-vitro and rodent-model, spanning TLR7/TLR8 receptor-reporter assays, interferon and cytokine induction readouts in cultured immune cells, and structure-activity studies across the imidazoquinoline scaffold. This research is preliminary and ongoing, describes laboratory systems only, and does not establish any human or animal outcome.
This product is sold strictly for in-vitro research and laboratory use only. It is not intended for human or animal consumption, diagnostic purposes, or therapeutic application.
By purchasing this product, you confirm that you are a qualified researcher operating within an appropriate laboratory environment and will use this compound in accordance with all applicable local, state, and federal regulations.
Amino Science Labs assumes no liability for misuse of this product outside of its intended research application.
No. Any results reported for imidazoquinoline amine derivatives are measurements recorded in specific experiments under defined laboratory conditions. They are not predictions for any other model, are not evidence of safety or efficacy, and cannot be extrapolated to humans or animals. Nothing on this page constitutes a health or performance claim.
No. This material is supplied strictly for in-vitro and laboratory research use by qualified researchers. It is not a drug, supplement, or food, is not intended for human or animal consumption or any diagnostic or therapeutic purpose, and nothing on this page constitutes medical advice.
